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Taiwan was a high-prevalent endemic area of HAV infection with 95 % of population having been infected with HAV before 15 years of age before 1981. In 1989, the infection rate of 15 years old dropped to 33 % and of 13 years old to 15 % in western plain region of Taiwan, however, that of mountain region in eastern and central Taiwan remains as high as before with 85 ~ 90 % infection rate of 7 ~ 14 years old. During those 8 years after 1981, the environmental sanitation in western plain region of Taiwan had showed remarkable improvement. The eastern mountain region had remained in poor sanitary environment during the same period. It has been proven that good environmental sanitation and individual hygienic habit would improve and eradicate the infection of HAV.